Example of clinical studies
Imprinted silicones showing MFIII Total Skin Rejuvenation & Revitalisation Program (Vegetal Placenta) before/after 3 weeks
Subject A
Subject B
After Treatment
Before Treatment
Before Treatment
After Treatment
Total Skin Rejuvenation & Revitalisation Program (Vegetal Placenta)
In addition to their role in maintaining the integrity of the skin and other tissues, MMPs have also been shown to be involved in angiogenesis.
With aging and in various conditions, the metabolic activity of cells such as fibroblasts may become disturbed. Such a disturbance may affect the equilibrium between production and breakdown of extra cellular matrice (Murphy and Reynolds, 1993). In these conditions, the balance between MMPs and inhibitor of MMPs is no longer respected so, that, in most cases, the enzymatic activity of MMPs predominates. Aging, long term sunlight exposure are all factors associated with an increased enzymatic activity of MMPs (Fischer, 1997). This activity eventually leads to the degradation of the collagen fiber meshwork.
In November 2007, Laboratoires Dom AVMM (Suisse) Inc. (No. 676998), a Swiss incorporated company, pioneers in Research & Development specialising indepth in Live Cell Therapy & Placental Therapy, went a step further by introducing an additional Vegetal Placenta in 'Cosmeceutical Form' to complement its existing 'Supplement Form' (VP Softgels) range. This New Cosmeceutical Range researched, developed, manufactured and approved in Switzerland under Swiss GMP stringent standards under the name of MFIII of Switzerland Total Skin Rejuvenation & Revitalisation Program.
MFIII of Switzerland Total Skin Rejuvenation & Revitalisation Program (Vegetal Placenta) or MFIII VP, in short, is manufactured according to an exclusive process, using state-of-the art molecular fractionation technology. The process is performed at controlled temperature with sophisticated ultrafiltration units to allow for the selection of specific molecules and to ensure the maintenance of their potency. The manufacturing steps are performed in accordance with the _____
_
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renewal, or turnover, a process based on an equilibrium between synthesis and degradation.
Collagen fibers are synthesized by cells such as skin fibroblasts. In addition to their anabolic activity, chondrocytes and fibroblasts also produce and secrete enzymes known as collagenase or matrix metalloproteinase (MMPs). MMPs represent a special class of enzymes that target and cleave the fibrous proteins of the ECM. Almost paradoxically, chondrocytes and fibroblasts also produce inhibitors of MMPs.
matrix metalloproteinase (MMP)
Swiss GMP (Good Manufacturing Practice) Swissmedic Certification No. 06-1258
Swiss Free Sales and Public Health Authorities Approval
Swiss Approval No: 07-0371-001
Approval Name: MFIII Total Skin
Rejuvenation & Revitalisation
Program under
Swiss Testing STS 347
Swiss Inspection SIS 077
Approval Name: MFIII Total Skin
Rejuvenation & Revitalisation
Program under
Swiss Testing STS 347
Swiss Inspection SIS 077
maintenance of their potency. The manufacturing steps are performed in accordance with the current provisions for Swiss Good Manufacturing Practice (GMP), ensuring a very high quality product.
The role of Matrix Metalloproteinases (MMPs) in MFIII of Switzerland VP
Proteins such as collagen, elastin and others are linked with others macromolecules such as glycoaminoglycans to form the extracellular matrix (ECM) components of all solid body tissues. Examples include cartilage, the fibrous sheaths of muscles, tendons and ligaments, and the dermal layer of the skin. The ECM components are in constant renewal, or turnover, a process based on an equilibrium between synthesis and degradation.
Biological activities
Age-related degradation of the extra-cellular matrix is closely associated with skin wrinkling and sagging. The effects of age-related increase in the activity of MMPs and collagenases is most visible at the level of skin.
In addition, the premature appearance of wrinkles and sagging are linked to long-term sunlight exposure (Fisher, 1997) and cigarette smoking (Kadunce, 1991).
Aging is a natural inevitable process. However, the damages caused by the age-related degeneration of extra-cellular matrix could be modulated if attempts are made to reestablish and maintain the equilibrium between extracallular matrix production and enzymatic activity of MMPs.
MFIII TSRRP (VP) has some whitening effect
properties on Pigmentation
properties on Pigmentation
metalloproteinase (MMPs). MMPs represent a special class of enzymes that target and cleave the fibrous proteins of the ECM. Almost paradoxically, chondrocytes and fibroblasts also produce inhibitors of MMPs. Almost paradoxically, chondrocytes and fibroblasts also produce inhibitors of MMPs. These inhibitors are important in restraining the degradative action of MMPs. A balance must therefore exist between these two opposite cellular activities in order to maintain or restore tissues matrix integrity.
In addition to their role in maintaining the integrity of the skin and other tissues, MMPs have also been shown to be involved in angiogenesis.
